Ritonavir
货号：
13872-10mg 基本售价：
616.0 元 规格：
10 mg
产品信息
概述| 货号 | 13872-10mg |
| 描述 | Ritonivir is an HIV protease inhibitor (EC50 = 25 nM) that also inhibits CYP3A4, the primary cytochrome P450 isoform that metabolizes protease inhibitors.1 Through CYP3A4 inhibition, low doses of ritonivir can reduce the metabolism of concomitantly administered protease inhibitiors, enhancing their bioavailability and efficacy.2,3 |
| 别名 | A-84538;ABT-538;NSC 693184;RTV; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kempf, D.J.,Shan, H.L.,Marsh, K.C., et al. Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy. Journal of Medicinal Chemistry 41(4), 602-617 (1998).
2.Zeldin, R.K. and Petruschke, R.A. Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients. Journal of Antimicrobial Chemotherapy 53(1), 4-9 (2004).
3.Croxtall, J.D. and Perry, C.M. Lopinavir/ritonavir: A review of its use in the management of HIV-1 infection. Drugs 70(14), 1885-1915 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 720.9 |
| 分子式 | C37H48N6O5S2 |
| CAS号 | 155213-67-5 |
| 稳定性 | ≥ 2 years |
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