Lomitapide
货号：
10009610-1mg 基本售价：
616.0 元 规格：
1 mg
产品信息
概述| 货号 | 10009610-1mg |
| 描述 | The microsomal triglyceride transfer protein (MTTP) is necessary for the assembly of very low-density lipoprotein (VLDL), a precursor of LDL, and its secretion from the liver. Preventing the activity of MTTP has been examined as a therapeutic strategy for reducing LDL production and plasma LDL cholesterol levels in patients with homozygous familial hypercholesterolemia (FH), an autosomal dominant disease caused by mutations in the LDL receptor gene.1 Lomitapide is a potent inhibitor of MTTP with an IC50 value of 8 nM in vitro.2 It has been shown to reduce the production of apolipoprotein B, thereby lowering LDL cholesterol levels, in both preclinical and clinical FH studies.1,3 |
| 别名 | AEGR 773;BMS 201038; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Vuorio, A.,Tikkanen, M.J., and Kovanen, P.T. Inhibition of hepatic microsomal triglyceride transfer protein - a novel therapeutic option for treatment of homozygous familial hypercholesterolemia. Vascular Health and Risk Management 10, 263-270 (2014).
2.Sulsky, R.,Robl, J.A.,Biller, S.A., et al. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorganic & Medicinal Chemistry Letters 14(20), 5067-5070 (2004).
3.Cuchel, M.,Bloedon, L.T.,Szapary, P.O., et al. Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. New England Journal of Medicine 356, 148-156 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 693.7 |
| 分子式 | C39H37F6N3O2 |
| CAS号 | 182431-12-5 |
| 稳定性 | ≥ 2 years |
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