| 货号 | 11342-1mg |
| 描述 | Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin A, a dominant analog of the isomers, is an inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types (average GI50 = 270 nM).1,2,3 Oligomycin A exhibits antifungal, antitumor, and nematocidal activities, but has poor solubility in water and other biocompatible solvents, which limits its clinical application.4 |
| 别名 | MCH 32; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Salomon, A.R.,Voehringer, D.W.,Herzenberg, L.A., et al. Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chemistry & Biology 8, 71-80 (2001). 2.Shin, Y.K.,Yoo, B.C.,Chang, H.J., et al. Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance. Cancer Research 65(8), 3162-3170 (2005). 3.Laatsch, H.,Kellner, M.,Wolf, G., et al. Oligomycin F, a new immunosuppressive homologue of oligomycin A. Journal of Antibiotics 46(9), 1334-1341 (1993). 4.Zu, Y.,Zhao, Q.,Zhao, X., et al. Process optimization of the preparation of oligomycin-loaded folate-conjugated chitosan nanoparticles as a tumor-targeted drug delivery system using a two-level factorial design method. Int.J.Nanomedicine 6, 3429-3441 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 791.1 |
| 分子式 | C45H74O11 |
| CAS号 | 579-13-5 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |