RTA 408
货号：
17854-1mg 基本售价：
602.0 元 规格：
1 mg
产品信息
概述| 货号 | 17854-1mg |
| 描述 | RTA 408 is a synthetic triterpenoid that binds Keap1 and attenuates the degradation of Nrf2 at concentrations ≤25 nM.1 In this way, it suppresses the generation of nitric oxide and pro-inflammatory cytokines in macrophages stimulated with IFN-γ.1 At higher concentrations, RTA 408 inhibits tumor cell growth (GI50 = 260 nM), blocks NF-κB signaling, and decreases levels of cyclin D1.1 Topical application of RTA 408 activates Nrf2 and provides cytoprotective effects.2,3 |
| 别名 | Omaveloxolone; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Probst, B.L.,Trevino, I.,McCauley, L., et al. RTA 408, a novel synthetic triterpenoid with broad anticancer and anti-inflammatory activity. PLoS One 10(4), 1-16 (2015).
2.Reisman, S.A.,Lee, C.Y.,Meyer, C.J., et al. Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin. Archives of Dermatological Research 306(5), 447-454 (2014).
3.Reisman, S.A.,Lee, C.Y.I.,Meyer, C.J., et al. Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis. Radiation Research 181, 512-520 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 554.7 |
| 分子式 | C33H44F2N2O3 |
| CAS号 | 1474034-05-3 |
| 稳定性 | ≥ 2 years |
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