LY2109761
货号：
15409-1mg 基本售价：
602.0 元 规格：
1 mg
产品信息
概述| 货号 | 15409-1mg |
| 描述 | LY2157299 is a small molecule inhibitor of the TGF-β receptor type 1/type II kinases (IC50 = 69 nM).1 It has been used to study the role of TGF-β signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where 5 μM of the compound completely disrupts Smad-2 phosphorylation, an immediate downstream target of the kinase activity.2 It can also suppress radiation-induced inflammatory cytokine signaling and proangiogenic genes, including ID1, in human primary fibrobalsts.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Li, H.y.,McMillen, W.T.,Heap, C.R., et al. Optimization of a dihydropyrrolopyrazole series of transforming growth factor-β type I receptor kinase domain inhibitors: Discovery of an orally bioavailable transforming growth factor-β receptor type I inhibitor as antitumor agent. Journal of Medicinal Chemistry 51(7), 2302-2306 (2008).
2.Melisi, D.,Ishiyama, S.,Sclabas, G.M., et al. LY2109761, a novel transforming growth factorβreceptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Molecular Cancer Therapeutics 7(4), 829-840 (2008).
3.Flechsig, P.,Dadrich, M.,Bickelhaupt, S., et al. LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-β and BMP-associated proinflammatory and proangiogenic signals. Clinical Cancer Research 18(13), 3616-3627 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 441.5 |
| 分子式 | C26H27N5O2 |
| CAS号 | 700874-71-1 |
| 稳定性 | ≥ 2 years |
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