CAY10589
货号：
13164-1mg 基本售价：
602.0 元 规格：
1 mg
产品信息
概述| 货号 | 13164-1mg |
| 描述 | Microsomal Prostaglandin E2 Synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. CAY10589 is a dual inhibitor of mPGES-1 (IC50 = 1.3 μM) and 5-LO (IC50 = 1.0 μM).1 It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. CAY10589 has minor effects on COX-1 and COX-2, inhibiting these enzymes 34% and 38.8%, respectively, at 10 μM.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Koeberle, A.,Zettl, H.,Greiner, C., et al. Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. Journal of Medicinal Chemistry 51, 8068-8076 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 470 |
| 分子式 | C25H28ClN3O2S |
| CAS号 | 1077626-52-8 |
| 稳定性 | ≥ 2 years |
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