| 货号 | 11428-500ug |
| 描述 | 4-deoxy Nivalenol is a natural type B trichothecene produced by certain species of the fungus Fusarium, particularly those found on cereal crops, including wheat, barley, oats, maize, and rye.1,2 This mycotoxin can induce vomiting, diarrhea, and weight loss as well as other physiological and toxicological effects.3 It inhibits protein biosynthesis, binds to peptidyl transferase, and inhibits the synthesis of RNA and DNA, contributing to immunotoxicity.4 It passes the blood-brain barrier at different rates in different animals and this may be related to anorexia.3 |
| 别名 | DON;NSC 269144;Vomitoxin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pestka, J.J., and Smolinski, A.T. Deoxynivalenol: Toxicology and potential effects on humans. J.Toxicol.Environ.Health B.Crit.Rev. 8(1), 39-69 (2005). 2.Maresca, M. From the gut to the brain: Journey and pathophysiological effects of the food-associated trichothecene mycotoxin deoxynivalenol. Toxins (Basel) 5(4), 784-820 (2013). 3.Bonnet, M.S.,Roux, J.,Mounien, L., et al. Advances in deoxynivalenol toxicity mechanisms: The brain as a target. Toxins (Basel) 4(11), 1120-1138 (2012). 4.Awad, W.,Ghareeb, K.,Böhm, J., et al. The toxicological impacts of the Fusarium mycotoxin, deoxynivalenol, in poultry flocks with special reference to immunotoxicity. Toxins (Basel) 5(5), 912-925 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 296.3 |
| 分子式 | C15H20O6 |
| CAS号 | 51481-10-8 |
| 稳定性 | ≥ 2 years |
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