| 货号 | 18485-5mg |
| 描述 | Dehydrocostus lactone is a natural sesquiterpene first isolated from costus root, which is used in traditional medicine.1 Dehydrocostus lactone has diverse anti-cancer properties in cells and animal models, causing cell cycle arrest, inducing apoptosis, diminishing multidrug resistance, and suppressing angiogenesis in cancer cells.2,3,4 It also has anti-inflammatory actions in cells, including the inhibition of signaling through STAT1 and STAT3.5,6 |
| 别名 | (-)-Dehydrocostus lactone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pandey, M.M.,Rastogi, S., and Rawat, A.K. Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant. Journal of Ethnopharmacology 110(3), 379-390 (2007). 2.Wang, C.Y.,Tsai, A.C.,Peng, C.Y., et al. Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways. PLoS One 7(2), (2012). 3.Lohberger, B.,Rinner, B.,Stuendl, N., et al. Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells. PLoS One 8(6), e66300 (2013). 4.Li, X.,Peng, Z., and Su, C. Potential anti-cancer activities and mechanisms of costunolide and dehydrocostuslactone. International Journal of Molecular Sciences 16(5), 10888-10906 (2015). 5.Butturini, E.,Cavalieri, E.,Carcereri de Prati, A., et al. Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation. PLoS One 6(5), e20174 (2011). 6.Scarponi, C.,Butturini, E.,Sestito, R., et al. Inhibition of inflammatory and proliferative responses of human keratinocytes exposed to the sesquiterpene lactones dehydrocostuslactone and costunolide. PLoS One 9(9), (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 230.3 |
| 分子式 | C15H18O2 |
| CAS号 | 477-43-0 |
| 稳定性 | ≥ 2 years |
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