Prostaglandin F2α diethyl amide
货号：
16023-1mg 基本售价：
588.0 元 规格：
1 mg
产品信息
概述| 货号 | 16023-1mg |
| 描述 | Prostaglandin F2α diethyl amide (PGF2α-NEt2) is an analog of PGF2α (Item No. 16010) in which the C-1 carboxyl group has been modified to an N-diethyl amide. PG esters have been shown to have ocular hypotensive activity.1 PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs.2 Studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various PGs to the free acids with a conversion efficiency of about 4 µg/g corneal tissue/hr.3 However, we find that dialkyl amides such as PGF2α-NEt2 are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids. These compounds may therefore be useful tools in elucidating the claim that PG amides have intrinsic intraocular hypotensive activity. |
| 别名 | Dinoprost diethyl amide;PGF2α diethyl amide;PGF2α-NEt2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bito, L.Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Experimental Eye Research 38, 181-184 (1984).
2.Woodward, D.F.,Krauss, A.H.P.,Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Survey of Ophthalmology 45, S337-S345 (2001).
3.Maxey, K.M.,Johnson, J.,Camras, C.B., et al. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. Survey of Ophthalmology 47(4), 34-40 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 409.6 |
| 分子式 | C24H43NO4 |
| 稳定性 | ≥ 2 years |
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