CAY10677
货号：
14744-1mg 基本售价：
588.0 元 规格：
1 mg
产品信息
概述| 货号 | 14744-1mg |
| 描述 | Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. Isoprenylcysteine carboxyl methyltransferase (Icmt) catalyzes the methylation of C-terminal prenylcysteine residues, the last step in this process. CAY10677 is an analog of the Icmt inhibitor cysmethynil (Item No. 14745) that was developed for improved solubility and cell permeability.1 CAY10677 inhibits Icmt with an IC50 value of 0.86 μM and demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC50s = 2.63 versus 27.4 μM, respectively) and human prostate cancer PC3 cells (IC50s = 2.55 versus 25.2 μM, respectively).1 |
| 别名 | Icmt Inhibitor 15; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ramanujulu, P.M.,Yang, T.,Yap, S.Q., et al. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). European Journal of Medicinal Chemistry 63, 378-386 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 407.6 |
| 分子式 | C25H37N5 |
| CAS号 | 1443253-20-0 |
| 稳定性 | ≥ 2 years |
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