CAY10640
货号：
10642-1mg 基本售价：
588.0 元 规格：
1 mg
产品信息
概述| 货号 | 10642-1mg |
| 描述 | Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM.1 CAY10640 demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model.1 |
| 别名 | sEHi;Soluble Epoxide Hydrolase Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rose, T.E.,Morisseau, C.,Liu, J.Y., et al. 1-aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: Structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. Journal of Medicinal Chemistry (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 371.4 |
| 分子式 | C17H20F3N3O3 |
| CAS号 | 1208549-68-1 |
| 稳定性 | ≥ 2 years |
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