| 货号 | 10009366-5mg |
| 描述 | Resveratrol is a potent phenolic antioxidant found in the skin of grapes and red wine that has anti-proliferative, anti-inflammatory, and cardioprotective properties.1 Piceatannol is a resveratrol analog formed by the cytochrome P450-catalyzed hydroxylation of resveratrol.2 Piceatannol exhibits potent anticancer properties by inducing apoptosis in BJAB Burkitt-like lymphoma cells with an ED50 value of 25 µM.3 Piceatannol also exhibits anti-proliferative and anti-inflammatory effects by inhibiting the activity of a wide range of tyrosine and serine/threonine protein kinases and suppressing NF-κB activation through inhibition of IκBα kinase.4,5 |
| 别名 | Astringenin;trans-Picetannol;trans-3,3,4,5-Tetrahydroxystilbene; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rotondo, S.,Rajtar, G.,Manarini, S., et al. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. British Journal of Pharmacology 123, 1691-1699 (1998). 2.Potter, G.A.,Patterson, L.H.,Wanogho, E., et al. The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYPIBI. British Journal of Cancer 86, 774-778 (2002). 3.Wieder, T.,Prokop, A.,Bagci, B., et al. Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts. Leukemia 15, 1735-1742 (2001). 4.Geahlen, R.L., and McLaughlin, J.L. Piceatannol (3,4,3,5-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor. Biochemical and Biophysical Research Communications 165(1), 241-245 (1989). 5.Ashikawa, K.,Majumdar, S.,Banerjee, S., et al. Piceatannol inhibits TNF-induced NF- k B activation and NF- k B-mediated gene expression through suppression of I k Bα kinase and p65 phosphorylation. Journal of Immunology 169, 6490-6497 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | >98% |
| 计算分子量 | 244.2 |
| 分子式 | C14H12O4 |
| CAS号 | 10083-24-6 |
| 稳定性 | ≥ 2 years |
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