| 货号 | 10554-5mg |
| 描述 | NG-amino-L-Arginine inhibits nNOS, iNOS, and eNOS with Ki values of 0.3, 3, and 2.5 μM, respectively.1,2 Inhibition is mediated by covalent alteration of the heme prosthetic group leading to inactivation of the enzyme.1,2,3NG-amino-L-Arginine can be used both in cell culture and in vivo.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wolff, D.J. and Lubeskie, A. Inactivation of nitric oxide synthase isoforms by diaminoguanidine and NG-amino-L-arginine. Archives of Biochemistry and Biophysics 325(2), 227-234 (1996). 2.Vuletich, J.L.,Lowe, E.R.,Jianmongkol, S., et al. Alteration of the heme prosthetic group of neuronal nitric-oxide synthase during inactivation by NG-amino-L-arginine in vitro and in vivo. Molecular Pharmacology 61(6), 110-118 (2002). 3.Lee, A.J.,Noon, K.R.,Jianmongkol, S., et al. Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group. Chemical Research in Toxicology 18(12), 1927-1933 (2005). 4.Peng, H.M.,Morishima, Y.,Clapp, K.M., et al. Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination. Biochemistry 48, 8483-8490 (2009). 5.Kellogg, D.L., Jr.,Zhao, J.L. and Wu, Y. Endothelial nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo. American Journal of Physiology.Heart and Circulatory Physiology 295, H123-H129 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 225.7 |
| 分子式 | C6H15N5O2 • HCl |
| CAS号 | 1031799-40-2 |
| 稳定性 | ≥ 2 years |
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