| 货号 | 9000785-1mg |
| 描述 | S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferases. 3-Deazaadenosine (3-DZA) is an inhibitor of SAH hydrolase (Ki = 3.9 μM).1,2 It has anti-inflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling.3,4 3-DZA also has antiviral and antibacterial activities.1,5,6 |
| 别名 | c3Ado;deaza-Ado;3-DZA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chiang, P.K. Biological effects of inhibitors of S-adenosylhomocysteine hydrolase. Pharmacology & Therapeutics 77(2), 115-134 (1998). 2.Gordon, R.K.,Ginalski, K.,Rudnicki, W.R., et al. Anti-HIV-1 activity of 3-deaza-adenosine analogs: Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. European Journal of Biochemistry 270, 3507-3517 (2003). 3.Jurgensen, C.H.,Huber, B.E.,Zimmerman, T.P., et al. 3Deazaadenosine inhibits leukocyte adhesion and ICAM1 biosynthesis in tumor necrosis factor-stimulated human endothelial cells. Journal of Immunology 144(2), 653-661 (1990). 4.Jeong, S.Y.,Ahn, S.G.,Lee, J.H., et al. 3-Deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-κB regulation. The Journal of Biological Chemisty 274(27), 18981-18988 (1999). 5.Long, M.C.,Allan, P.W.,Luo, M.Z., et al. Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth. Journal of Antimicrobial Chemotherapy 59, 118-121 (2007). 6.Huggins, J.,Zhang, Z.X., and Bray, M. Antiretroviral drug therapy of filovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit ebola virus in vitro and in a lethal mouse model. Journal of Infectious Diseases 179(1), S240-S247 (1999). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 266.3 |
| 分子式 | C11H14N4O4 |
| CAS号 | 6736-58-9 |
| 稳定性 | ≥ 2 years |
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