MLR-1023
货号：
21496-5mg 基本售价：
560.0 元 规格：
5 mg
产品信息
概述| 货号 | 21496-5mg |
| 描述 | MLR-1023 is an allosteric activator of Lyn kinase (EC50 = 63 nM).1 It has no significant activity against a panel of related kinases. MLR-1023 is orally bioavailable and reduces blood glucose levels in mice subjected to an oral glucose tolerance test.1 This effect is insulin-dependent, with MLR-1023 increasing insulin receptor sensitivity.2 MLR-1023 produces a dose-dependent and durable glucose-lowering effect in chronically treated db/db mice without causing weight gain.2 |
| 别名 | CP 26,154;NSC 314335; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Saporito, M.S.,Ochman, A.R.,Lipinski, C.A., et al. MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J. Pharmacol. Exp. Ther. 342(1), 15-22 (2012).
2.Ochman, A.R.,Lipinski, C.A.,Handler, J.A., et al. The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J. Pharmacol. Exp. Ther. 342(1), 23-32 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 202.2 |
| 分子式 | C11H10N2O2 |
| CAS号 | 41964-07-2 |
| 稳定性 | ≥ 2 years |
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