ML-385
货号：
21114-1mg 基本售价：
560.0 元 规格：
1 mg
产品信息
概述| 货号 | 21114-1mg |
| 描述 | ML-385 is an inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2; IC50 = 1.9 µM) that blocks downstream target gene expression.1 It substantially enhances cytotoxicity in non-small cell lung cancer (NSCLC) cells treated with platinum-based drugs.1 ML-385 shows specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Singh, A.,Venkannagari, S.,Oh, K.H., et al. Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors. ACS Chem Biol. 11(11), 3214-3225 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 511.6 |
| 分子式 | C29H25N3O4S |
| CAS号 | 846557-71-9 |
| 稳定性 | ≥ 2 years |
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