Tivozanib (hydrate)
货号：
18493-1mg 基本售价：
560.0 元 规格：
1 mg
产品信息
概述| 货号 | 18493-1mg |
| 描述 | Tivozanib is an orally available, selective VEGFR inhibitor with IC50 values of 0.21, 0.16, and 0.24 nM for VEGFR1, VEGFR2, and VEGFR3, respectively.1,2 It can also inhibit c-Kit and PDGFRβ with IC50 values of 1.63 and 1.72 nM, respectively.2 When administered to athymic rats, tivozanib was shown to decrease the microvessel density within tumor xenografts and attenuate VEGFR2 phosphorylation levels in tumor endothelium.2 It also displays antitumor activity against a wide variety of human tumor xenografts, including lung, breast, colon, ovarian, pancreas, and prostate cancer.2 |
| 别名 | AV-951;KRN 951; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bhargava, P., and Robinson, M.O. Development of second-generation VEGFR tyrosine kinase inhibitors: Current status. Curr.Oncol.Rep. 13(2), 103-111 (2011).
2.Nakamura, K.,Taguchi, E.,Miura, T., et al. KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties. Cancer Res. 66(18), 9134-9142 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 472.9 |
| 分子式 | C22H19ClN4O5 • H2O |
| CAS号 | 682745-40-0 |
| 稳定性 | ≥ 2 years |
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