| 货号 | 16496-1mg |
| 描述 | Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin (Item No. 10005169). It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM).1 Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 µM), which has an important role in the excretion of xenobiotics at the kidney and liver.2 It has also been reported to potentiate the neurological actions of nerve growth factor, diminish the cardiotoxic impact of doxorubicin, and have beneficial anti-cancer effects.3,4,5,6 |
| 别名 | 3-O-methyl Quercetin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Nagao, A.,Seki, M. and Kobayashi, H. Inhibition of xanthine oxidase by flavonoids. Bioscience, Biotechnology, and Biochemistry 63(10), 1787-1790 (1999). 2.Kawasaki, T.,Ito, H. and Omote, H. Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1. Biological and Pharmaceutical Bullentin 37(2), 292-297 (2014). 3.Xu, S.L.,Choi, R.C.Y.,Zhu, K.Y., et al. Isorhamnetin, a flavonol aglycone from Ginkgo biloba L., induces neuronal differentiation of cultured PC12 cells: Potentiating the effect of nerve growth factor. Evidence-Based Complementary and alternative Medicine 2012, 1-12 (2012). 4.Sun, J.,Sun, G.,Meng, X., et al. Isorhamnetin protects against doxorubicin-induced cardiotoxicity in vivo and in vitro. PLoS One 8(5), 1-14 (2014). 5.Ramachandran, L.,Manu, K.A.,Shanmugam, M.K., et al. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. The Journal of Biological Chemisty 287(45), 38028-38040 (2012). 6.Saud, S.M.,Young, M.R.,Jones-Hall, Y.L., et al. Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin. Cancer Research 73(17), 5473-5484 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 316.3 |
| 分子式 | C16H12O7 |
| CAS号 | 480-19-3 |
| 稳定性 | ≥ 2 years |
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