| 货号 | 16483-1mg |
| 描述 | Nε-(1-Carboxymethyl)-L-lysine (CML) is an advanced glycation end product (AGE), produced by the oxidative modification of glycated proteins during oxidative stress.1,2,3 Levels of CML increase with aging and during diabetes, cancer, vascular disease, and other pathologies marked by oxidative stress.1,4,5 CML activates the membrane-bound receptor for AGEs (RAGE), triggering signaling through MAPKs and NF-κB, whereas truncation of RAGE produces a soluble protein that binds CML and reduces signaling.6,7 |
| 别名 | CML; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Requena, J.R.,Ahemd, M.U.,Fountain, C.W., et al. Carboxymethylethanolamine, a biomarker of phospholipid modification during the maillard reaction in vivo. The Journal of Biological Chemisty 272(28), 17473-17479 (1997). 2.Ahmed, M.U.,Brinkmann, F.E.,Degenhardt, T.P., et al. Nε-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins. Biochemistry Journal 324(Pt 2), 565-570 (1997). 3.Schleicher, E.D.,Wagner, E. and Nerlich, A.G. Increased accumulation of the glycoxidation product Nε-(carboxymethyl)lysine in human tissues in diabetes and aging. Journal of Clinical Investigation 99(3), 457-468 (1997). 4.Campbell, D.J.,Somaratne, J.B.,Jenkins, A.J., et al. Impact of type 2 diabetes and the metabolic syndrome on myocardial structure and microvasculature of men with coronary artery disease. Cardiovascular Diabetology 10, 1-14 (2011). 5.Brouwers, O.,de Vos-Houben, J.M.J.,Niessen, P.M.G., et al. Mild oxidative damage in the diabetic rat heart is attenuated by glyoxalase-1 overexpression. International Journal of Molecular Sciences 14(8), 15724-15739 (2013). 6.Schmidt, A.M.,Yan, S.D.,Yan, S.F., et al. The biology of the receptor for advanced glycation end products and its ligands. Biochimica et Biophysica Acta 1498(2-3), 99-111 (2000). 7.Moy, K.A.,Jiao, L.,Freedman, N.D., et al. Soluble receptor for advanced glycation end products and risk of liver cancer. Hepatology 57(6), 2338-2345 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 204.2 |
| 分子式 | C8H16N2O4 |
| CAS号 | 1404817 |
| 稳定性 | ≥ 2 years |
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