| 货号 | 14532-1mg |
| 描述 | Platelet-activating factor (PAF) is a biologically active phospholipid that activates platelets, polymorphonuclear leukocytes, monocytes, and macrophages.1 PAF also increases vascular permeability, decreases cardiac output, induces hypotension, stimulates uterine contraction, and has been implicated in pathological processes, such as inflammation and allergy.2 Apafant is a water soluble, selective PAF receptor antagonist that inhibits PAF binding to human PAF receptors with a Ki value of 9.9 nM.3 Apafant displays anti-inflammatory, antiangiogenic, and anticancer activity.4,3,5 |
| 别名 | WEB 2086; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Prescott, S.M.,Zimmerman, G.A. and McIntyre, T.M. Platelet-activating factor. The Journal of Biological Chemisty 265, 17381-17384 (1990). 2.Snyder, F. Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. American Journal of Physiology.Cell Physiology 259, C697-C708 (1990). 3.Kato, M.,Imoto, K.,Miyake, H., et al. Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs. Journal of Pharmacological Sciences 95(4), 435-442 (2004). 4.Bielenberg, G.W.,Wagener, G. and Beck, T. Infarct reduction by the platelet activating factor antagonist apafant in rats. Stroke 23(1), 98-103 (1992). 5.Cellai, C.,Laurenzana, A.,Vannucchi, A.M., et al. Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. British Journal of Cancer 94, 1637-1642 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 456 |
| 分子式 | C22H22ClN5O2S |
| CAS号 | 105219-56-5 |
| 稳定性 | ≥ 2 years |
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