Trilostane
货号：
14164-5mg 基本售价：
560.0 元 规格：
5 mg
产品信息
概述| 货号 | 14164-5mg |
| 描述 | 3β-hydroxysteroid dehydrogenase (3β-HSD) type 1 and type 2 isoforms are key enzymes for the biosynthesis of all active steroid hormones. 3β-HSD1 (type I) is expressed in placenta and peripheral tissues including breast tumors, whereas 3β-HSD2 (type 2) is expressed in the adrenal gland, ovary, and testis. Trilostane is an inhibitor of the 3β-HSDs: 3β-HSD1 and 3β-HSD2 with Ki values of 0.10 and 1.60 μM, respectively.1 Trilsotane has been approved for use in the treatment of Cushing’s syndrome in dogs to reduce cortisol, aldosterone, and corticosterone levels.2 Because human 3β-HSD (type 1) is a critical enzyme in the conversion of DHEA to estradiol in breast tumors, trilostane is also of interest for the treatment of breast cancer in postmenopausal women.3 |
| 别名 | Desopan;Modrefen;Vetoryl;WIN 24,540; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Thomas, J.L.,Mack, V.L.,Glow, J.A., et al. Structure/function of the inhibition of human 3β-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane. Journal of Steroid Biochemistry and Molecular Biology 111(1-2), 66-73 (2008).
2.Machida, T.,Uchida, E.,Matsuda, K., et al. Aldosterone-, corticosterone- and cortisol-secreting adrenocortical carcinoma in a dog: Case report. Journal of Veterinary Medical Science 70(3), 317-320 (2008).
3.Thomas, J.L.,Bucholtz, K.M. and Kacsoh, B. Selective inhibition of human 3β-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer. Journal of Steroid Biochemistry and Molecular Biology 125(1-2), 57-65 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 329.4 |
| 分子式 | C20H27NO3 |
| CAS号 | 13647-35-3 |
| 稳定性 | ≥ 2 years |
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