Bleomycin (sulfate)
货号：
13877-1mg 基本售价：
560.0 元 规格：
1 mg
产品信息
概述| 货号 | 13877-1mg |
| 描述 | Bleomycin is a glycopeptide antitumor antibiotic produced by the bacterium S. verticillus. Its mechanism of action causes single- and double-strand DNA breaks in tumor cells, which interrupts the cell cycle.1 Bleomycin is thought to achieve this by chelating metal ions, producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.1 Bleomycin has been used for the treatment of Hodgkin’s lymphoma in combination with doxorubicin, squamous cell carcinomas, testicular cancer, as well as in animal models of pulmonary fibrosis.2,3 |
| 别名 | Blenoxane; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hecht, S.M. Bleomycin: New perspectives on the mechanism of action. Journal of Natural Products 63, 158-168 (2000).
2.Martinelli, G.,Cocorocchio, E.,Saletti, P.C., et al. Efficacy of vinblastine, bleomycin, methotrexate (VBM) combination chemotherapy with involved field radiotherapy in early stage (I-IIA) Hodgkin disease patients. Leukemia and Lymphoma 44(11), 1919-1923 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1513.6 |
| 分子式 | C55H84N17O21S3 • XH2SO4 |
| CAS号 | 9041-93-4 |
| 稳定性 | ≥ 2 years |
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