YM-201636
货号：
13576-1mg 基本售价：
560.0 元 规格：
1 mg
产品信息
概述| 货号 | 13576-1mg |
| 描述 | PIKfyve is a phosphoinositide kinase (PIK) that contains a FYVE-type zinc finger domain, which binds phosphatidylinositol 3-phosphate (PI3P). PIKfyve phosphorylates PI3P to produce PI-(3,5)-P2, which is involved in cellular processes including membrane trafficking and cytoskeletal reorganization. YM-201636 is a cell-permeable and selective inhibitor of PIKfyve (IC50 = 33 nM).1 It reversibly impairs endosomal trafficking in NIH3T3 cells, mimicking the effect produced by depleting PIKfyve with siRNA.1 YM-201636 also blocks retroviral exit by budding from cells, apparently by interfering with the endosomal sorting complex required for transport (ESCRT) machinery.1 In adipocytes, YM-201636 also inhibits basal and insulin-activated 2-deoxyglucose uptake (IC50 = 54 nM).2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jefferies, H.B.J.,Cooke, F.T.,Jat, P., et al. A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding. EMBO reports 9(2), 164-170 (2008).
2.Ikonomov, O.C.,Sbrissa, D., and Shisheva, A. YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. Biochemical and Biophysical Research Communications 382, 566-570 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 467.5 |
| 分子式 | C25H21N7O3 |
| CAS号 | 371942-69-7 |
| 稳定性 | ≥ 2 years |
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