| 货号 | 13333-1mg |
| 描述 | Bisindolylmaleimide VIII (BIM VIII) is a selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC.1,2 This compound exhibits some degree of PKC isozyme specificity with preference for PKCα over PKCβI, PKCβII, PKCγ, or PKCε (IC50s = 53, 195, 163, 213, and 175 nM, respectively).1 At 10 µM BIM VIII does not inhibit the tyrosine phosphorylation or the activation of phospholipase C γ1.3 BIM VIII inhibits carbachol-evoked noradrenaline release from human SH-SY5Y neuroblastoma cells with an IC50 value of 600 nM.4 |
| 别名 | BIM VIII;Ro 31-7549; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wilkinson, S.E.,Parker, P.J., and Nixon, J.S. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochemistry Journal 294, 335-337 (1993). 2.Zhang, C.,Hirasawa, N., and Beaven, M.A. Antigen activation of mitogen-activated protein kinase in mast cells through protein kinase C-dependent and independent pathways. Journal of Immunology 158, 4968-4975 (1997). 3.Ozawa, K.,Yamada, K.,Kazanietz, M.G., et al. Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells. The Journal of Biological Chemisty 268(4), 2280-2283 (1993). 4.Turner, N.A.,Walker, J.H.,Ball, S.G., et al. Phorbol ester-enhanced noradrenaline secretion correlates with the presence and activity of protein kinase C-α in human SH-SY5Y neuroblastoma cells. Journal of Neurochemistry 66, 2381-2389 (1996). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 458.5 |
| 分子式 | C24H22N4O2 • C2H4O2 |
| CAS号 | 138516-31-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |