Eprosartan (mesylate)
货号：
11578-10mg 基本售价：
560.0 元 规格：
10 mg
产品信息
概述| 货号 | 11578-10mg |
| 描述 | Angiotensin II, as part of the renin-angiotensin-aldosterone system, facilitates a sympathetic nervous system response mediated by the angiotensin II type 1 (AT1) receptor, causing vasoconstriction and subsequent increase in blood pressure. It potentiates noradrenaline release from sympathetic nerve terminals at the presynaptic level as well as amplifies the α-adrenoceptor-mediated vasoconstrictor response to endogenous noradrenaline. Angiotensin II receptor blockers (ARBs) are a major class of therapeutics designed to lower blood pressure and to provide cardiovascular protection.1,2 Eprosartan (mesylate) is a competitive AT1 receptor antagonist with IC50 values ranging from 1.4 – 3.9 nM and an elimination half-life of five to seven hours.3 Eprosartan is structurally distinct from other noncompetitive ARBs in that it does not contain a biphenyl, tetrazole moiety and blocks angiotensin II receptors on both sympathetic nerve terminals and blood vessels.4 |
| 别名 | SKF 108566J; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Munger, M.A. Use of angiotensin receptor blockers in cardiovascular protection: Current evidence and future directions. PT 36(1), 22-40 (2011).
2.Burnier, M. Angiotensin II type 1 receptor blockers. Circulation 103, 904-912 (2001).
3.Blankestijn, P.J. and Rupp, H. Clinical profile of eprosartan: A different angiotensin II receptor blocker. Cardiovasc.Hematol.Agents Med.Chem. 6(4), 253-257 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 520.6 |
| 分子式 | C23H24N2O4S • CH3SO3H |
| CAS号 | 144143-96-4 |
| 稳定性 | ≥ 2 years |
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