| 货号 | 11331-1mg |
| 描述 | The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.1,2,3,4 This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.5,6,7,8 Cytochalasin E is an epoxide-containing analog of cytochalasin B (Item No. 11328) which potently and selectively inhibits the growth of endothelial cells (IC50< 1 nM), impairing angiogenesis and tumor growth.9 This cytochalasin does not inhibit glucose transport or HIV-1 protease activity.10,11,12 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brenner, S.L. and Korn, E.D. The effects of cytochalasins on actin polymerization and actin ATPase provide insights into the mechanism of polymerization. The Journal of Biological Chemisty 255(3), 841-844 (1980). 2.Lin, D.C.,Tobin, K.D.,Grumet, M., et al. Cytochalasins inhibit nuclei-induced actin polymerization by blocking filament elongation. Journal of Cell Biology 84, 455-460 (1980). 3.Ostlund, R.E., Jr.,Leung, J.T. and Hajek, S.V. Regulation of microtubule assembly in cultured fibroblasts. Journal of Cell Biology 85, 386-391 (1980). 4.Pinder, J.C. and Gratzer, W.B. Structural and dynamic states of actin in the erythrocyte. Journal of Cell Biology 96(3), 768-775 (1983). 5.Flaumenhaft, R.,Dilks, J.R.,Rozenvayn, N., et al. The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretion. Blood 105(10), 3879-3887 (2005). 6.Taheri-Talesh, N.,Horio, T.,Araujo-Bazán, L., et al. The tip growth apparatus of Aspergillus nidulans. Molecular Biology of the Cell 19, 1439-1449 (2008). 7.dos Santos, T.,Varela, J.,Lynch, I., et al. Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines. PLoS One 6(9), 1-10 (2011). 8.Nightingale, T.D.,White, I.J.,Doyle, E.L., et al. Actomyosin II contractility expels von Willebrand factor from Weibel-Palade bodies during exocytosis. Journal of Cell Biology 194(4), 613-629 (2011). 9.Udagawa, T.,Yuan, J.,Panigrahy, D., et al. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Journal of Pharmacology and Experimental Therapeutics 294(2), 421-427 (2000). 10.Kletzien, R.F.,Perdue, J.F. and Springer, A. Cytochalasin A and B. Inhibition of sugar uptake in cultured cells. The Journal of Biological Chemisty 247(9), 2964-2966 (1972). 11.Griffin, J.F.,Rampal, A.L. and Jung, C.Y. Inhibition of glucose transport in human erythrocytes by cytochalasins: A model based on diffraction studies. Proceedings of the National Academy of Sciences of the United States of America 79, 3759-3763 (1982). 12.Lombardo, Y.B.,Drago, S.,Chicco, A., et al. Long-term administration of a sucrose-rich diet to normal rats: Relationship between metabolic and hormonal profiles and morphological changes in the endocrine pancreas. Metabolism 45(12), 1527-1532 (1996). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 495.6 |
| 分子式 | C28H33NO7 |
| CAS号 | 36011-19-5 |
| 稳定性 | ≥ 2 years |
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