17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
货号：
9000346-25ug 基本售价：
546.0 元 规格：
25 ug
产品信息
概述| 货号 | 9000346-25ug |
| 描述 | Docosahexaenoic acid (DHA; Item No. 90310) is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. 17-keto-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity.1,2,3 It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 µM).3 |
| 别名 | EFOX;17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA;17-oxo-DHA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Butovich, I.A. A one-step method of 10,17-dihydro(pero)xydocosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid synthesis by soybean lipoxygenase. Journal of Lipid Research 47, 854-863 (2006).
2.Jie, M.S.F.L.K. and Pasha, M.K. Fatty acids, fatty acid analogues and their derivatives. Natural Product Reports 607-629 (1998).
3.Groeger, A.L.,Cipollina, C.,Cole, M.P., et al. Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids. Nature Chemical Biology (2010).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥90% |
| 计算分子量 | 342.5 |
| 分子式 | C22H30O3 |
| CAS号 | 1233715-28-0 |
| 稳定性 | ≥ 6 months |
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