1,4-DPCA
货号：
71220-5mg 基本售价：
546.0 元 规格：
5 mg
产品信息
概述| 货号 | 71220-5mg |
| 描述 | The pro-angiogenic factor HIF-1α is targeted for destruction in non-hypoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH).1 Inhibitors of prolyl 4-hydroxylase are potentially useful in controlling excess collagen deposition in pathological fibrosis. 1,4-DPCA is a competitive inhibitor of prolyl 4-hydroxylase in embryonic chick tendon cells and of collagen hydroxylation in human foreskin fibroblasts with an IC50 value of 3.6 and 2.4 µM, respectively.2 β-oxocarboxylic acids such as 1,4-DPCA have also been found to inhibit the asparaginyl-hydroxylase, factor inhibiting HIF (FIH), with an IC50 value of 60 µM.3 |
| 别名 | 1,4-dihydrophenonthrolin-4-one-3-Carboxylic acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jaakkola, P.,Mole, D.R.,Tian, Y.M., et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468-472 (2001).
2.Franklin, T.J.,Morris, W.P.,Edwards, P.N., et al. Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones. Biochemistry Journal 353, 333-338 (2001).
3.Banerji, B.,Conejo-Garcia, A.,McNeill, L.A., et al. The inhibiton of factor inhibiting hypoxia-inducible factor (FIH) by β-oxocarboxylic acids. Chemical Communications 5438-5440 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 240.2 |
| 分子式 | C13H8N2O3 |
| CAS号 | 331830-20-7 |
| 稳定性 | ≥ 2 years |
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