| 货号 | 21844-25g |
| 描述 | Bithionol is an anthelmintic drug. Formulations containing bithionol have demonstrated efficacy against cestodes and trematodes, as well as other parasitic worms.1,2,3 Bithionol inhibits host caspases, including caspases-1, -3, -6, -7, and -9, which act as hub proteins that mediate the lethality of multiple pathogenic agents.4 By blocking host caspases, bithionol reduces the detrimental effects of anthrax lethal toxin, diphtheria toxin, cholera toxin, P. aeruginosa exotoxin A, Botulinum neurotoxin, ricin, and Zika virus.4 Bithionol also inhibits NF-κB activation by blocking phosphorylation of IκBα (IC50 = 15.8 µM in a reporter gene assay).5 |
| 别名 | CP 3438;NSC 9872;NSC 47129; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Arjona, R.,Riancho, J.A.,Aguado, J.M., et al. Fascioliasis in developed countries: A review of classic and aberrant forms of the disease. Medicine (Baltimore) 74(1), 13-23 (1995). 2.Choi, D.W. Paragonimus and paragonimiasis in Korea. Kisaengchunghak Chapchi. 28 Suppl., 79-102 (1990). 3.Cruz, A.C. Treatment of human taeniasis in the Philippines: A review. Southeast Asian J. Trop. Med. Public Health 22 Suppl, 271-274 (1991). 4.Leonardi, W.,Zilbermintz, L.,Cheng, L.W., et al. Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus. Sci. Rep. 6:34475, 1-12 (2016). 5.Miller, S.C.,Huang, R.,Sakamuru, S., et al. Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action. Biochem. Pharmacol. 79(9), 1272-1280 (2016). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 356.1 |
| 分子式 | C12H6Cl4O2S |
| CAS号 | 97-18-7 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |