Fascaplysin (chloride)
货号：
21715-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 21715-1mg |
| 描述 | Fascaplysin is an inhibitor of cyclin D kinase 4/ cyclin D1 (IC50 = 0.35 μM) that was originally isolated from the marine sponge Thorectandra.1 It is significantly less selective for Cdk6/cyclin D1 (IC50 = 3.4 μM) and does not inhibit other Cdks and tyrosine kinases.1 Fascaplysin is reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1arrest.1 Inhibition of Cdk4 via fascaplysin has been shown to induce peroxisome-proliferator-activated receptor γ-1α deacetylation (IC50 = 0.7 µM) and has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism.2 |
| 别名 | NSC 622398; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Soni, R.,Muller, L.,Furet, P., et al. Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product. Biochem. Biophys. Res. Commun. 275(3), 877-884 (2000).
2.Lee, Y.,Dominy, J.E.,Choi, Y.J., et al. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature 510(7506), 547-551 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 306.8 |
| 分子式 | C18H11N2O • Cl |
| CAS号 | 114719-57-2 |
| 稳定性 | ≥ 2 years |
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