4-oxo Docosahexaenoic Acid
货号：
21373-25ug 基本售价：
546.0 元 规格：
25 ug
产品信息
概述| 货号 | 21373-25ug |
| 描述 | 4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA (Item No. 90310) with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 µM, however it increased proliferation of MCF-7 cells.1 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 µM.2 |
| 别名 | 4-oxo DHA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pogash, T.J.,El-Bayoumy, K.,Amin, S., et al. Oxidized derivative of docosahexaenoic acid preferentially inhibit cell proliferation in triple negative over luminal breast cancer cells. In Vitro Cell. Dev. Biol. Anim. 51(2), 121-127 (2015).
2.Itoh, T.,Fairall, L.,Amin, K., et al. Structural basis for the activation of PPARγ by oxidized fatty acids. Nat. Struct. Mol. Biol. 15(9), 924-931 (2008).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥90% |
| 计算分子量 | 342.5 |
| 分子式 | C22H30O3 |
| CAS号 | 845673-74-7 |
| 稳定性 | ≥ 1 year |
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