Naftopidil (hydrochloride)
货号：
21122-25mg 基本售价：
546.0 元 规格：
25 mg
产品信息
概述| 货号 | 21122-25mg |
| 描述 | Naftopidil is an α1-adrenergic receptor antagonist that competitively inhibits α-adrenoceptor-mediated contractions induced by noradrenaline with pA2 values of 6.73-8.15 in various blood vessels from dog, rabbit, guinea pig, and rat.1 It binds to the cloned human α1-adrenergic receptors with Ki values of 3.7, 20, and 1.2 nM for α1A, α1B and α1D, respectively.2 Clinical formulations of naftopidil are used in the treatment of benign prostatic hyperplasia in Japan.2 Naftopidil also exhibits antiproliferative activity, inhibiting the growth of androgen-sensitive LNcaP cells and androgen-insensitive PC-3 cancer cell lines with IC50 values of 22.2 and 33.2 µM, respectively.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Muramatsu, I.,Yamanaka, K. and Kigoshi, S. Pharmacological profile of the novel alpha-adrenoceptor antagonist KT-611 (naftopidil). Jpn. J. Pharmacol. 55(3), 391-398 (1991).
2.Masumori, N. Naftopidil for the treatment of urinary symptoms in patients with benign prostatic hyperplasia. Ther. Clin. Risk Manag. 7, 227-238 (2011).
3.Kanda, H.,Ishii, K.,Ogura, Y., et al. Naftopidil, a selective α-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrest. Int. J. Cancer 122(2), 444-451 (2008).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 429 |
| 分子式 | C24H28N2O3 • HCl |
| CAS号 | 1164469-60-6 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
