| 货号 | 20918-500ug |
| 描述 | Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 µM), which is an enzyme involved in the biosynthesis of cholesterol.1,2 It has antitumor properties, such as decreasing proliferation and inducing apoptosis in many cancer cell lines and slowing tumor growth in a mouse xenograft model.3 It can also decrease Hedgehog pathway signaling in cancer cells. Formulations containing triparanol were discontinued in the 1960s due to serious adverse side effects, including rapid cataract development.4,5 |
| 别名 | MER-29;NSC 65345; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Avigan, J.,Steinberg, D.,Vroman, H.E., et al. Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29. J. Biol. Chem. 235(11), 3123-3126 (1960). 2.Bae, S.-H. and Paik, Y.-K. Cholesterol biosynthesis from lanosterol: Development of a novel assay method and characterization of rat liver microsomal lanosterol D24-reductase. Biochem. J. 326, 609-616 (1997). 3.Bi, X.,Han, X.,Zhang, F., et al. Triparanol suppresses human tumor growth in vitro and in vivo. Biochem. Biophys. Res. Commun. 425(3), 613-618 (2012). 4.Endo, A. A historical perspective on the discovery of statins. Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci. 86(5), 484-493 (2010). 5.Laughlin, R.C. and Carey, T.F. Cataracts in patients treated with triparanol. JAMA 181(4), 339-340 (1962). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 438 |
| 分子式 | C27H32ClNO2 |
| CAS号 | 78-41-1 |
| 稳定性 | ≥ 2 years |
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