| 货号 | 20294-5g |
| 描述 | Hyodeoxycholic acid (HDCA) is a secondary bile acid. It is produced from lithocholic acid (Item No. 20253) by bacterial action in the colon.1,2,3 Dietary supplementation with HDCA results in decreased plasma VLDL and LDL cholesterol and reduced atherosclerosis in mice.4,5 Serum levels of HDCA are increased significantly in Crohn’s disease and ulcerative colitis.6 |
| 别名 | HDCA;α-Hyodeoxycholic Acid;NSC 60672; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Einarsson, K. On the formation of hyodeoxycholic acid in the rat. Bile acids and steroids 154. J. Biol. Chem. 241(3), 534-539 (1966). 2.Madsen, D.,Beaver, M.,Chang, L., et al. Analysis of bile acids in conventional and germfree rats. J. Lipid. Res. 17(2), 107-111 (1976). 3.Sacquet, E.,Parquet, M.,Riottot, M., et al. Intestinal absorption, excretion, and biotransformation of hyodeoxycholic acid in man. J. Lipid. Res. 24(5), 604-613 (1983). 4.Sehayek, E.,Ono, J.G.,Duncan, E.M., et al. Hyodeoxycholic acid efficiently suppresses atherosclerosis formation and plasma cholesterol levels in mice. J. Lipid. Res. 42(8), 1250-1256 (2001). 5.Shih, D.M.,Shaposhnik, Z.,Meng, Y., et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 27(9), 3805-3817 (2013). 6.Gnewuch, C.,Liebisch, G.,Langmann, T., et al. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. World J. Gastroenterol. 15(25), 3134-3141 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 392.6 |
| 分子式 | C24H40O4 |
| CAS号 | 83-49-8 |
| 稳定性 | ≥ 2 years |
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