GDC-0623
货号：
19479-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 19479-1mg |
| 描述 | GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki = 0.13 nM in the presence of ATP).1 It inhibits the proliferation of A375 BRAF(V600E) and HCT116 KRAS(G13D)-mutant cancer cell lines with EC50 values of 7 and 42 nM, respectively.1 GDC-0623 inhibits ERK and BIM phosphorylation resulting in upregulation and stabilization of pro-apoptotic BIM protein in KRAS mutant and wild-type HCT116 cells and in KRAS mutant GW620 cells.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hatzivassiliou, G.,Haling, J.R.,Chen, H., et al. Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature 501(7466), 232-236 (2013).
2.Zaanan, A.,Okamoto, K.,Kawakami, H., et al. The mutant KRAS gene up-regulates BCL-XL protein via STAT3 to confer apoptosis resistance that is reversed by BIM protein induction and BCL-XL antagonism. J. Biol. Chem. 290(39), 23838-23849 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 456.2 |
| 分子式 | C16H14FIN4O3 |
| CAS号 | 1168091-68-6 |
| 稳定性 | ≥ 2 years |
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