3PO
货号：
19276-5mg 基本售价：
546.0 元 规格：
5 mg
产品信息
概述| 货号 | 19276-5mg |
| 描述 | 3PO is a competitive inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 3 (PFKFB3; IC50 = 23 µM) that causes a rapid reduction in fructose-2,6-bisphosphate (F2,6BP), glucose uptake, and lactate secretion.1,2 This is followed by a reduction in the steady-state concentration of ATP and NADH, resulting in cell cycle arrest in Jurkat T cell leukemia cells.1,2 3PO is selectively cytostatic to ras-transformed bronchial epithelial cells relative to normal bronchial epithelial cells.1 3PO markedly reduces intracellular F2,6BP, glucose uptake, and growth of established tumors in mice.1 It also blocks angiogenesis, reducing vessel sprouting in endothelial cell spheroids, zebrafish embryos, and the postnatal mouse retina by inhibiting endothelial cell proliferation and migration.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Clem, B.,Telang, S.,Clem, A., et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Molecular Cancer Therapeutics 7(1), 110-120 (2008).
2.Clem, B.F.,ONeal, J.,Tapolsky, G., et al. Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Molecular Cancer Therapeutics 12(8), 1461-1470 (2013).
3.Schoors, S.,De Bock, K.,Cantelmo, A.R., et al. Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metabolism 19(1), 37-48 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 210.2 |
| 分子式 | C13H10N2O |
| CAS号 | 18550-98-6 |
| 稳定性 | ≥ 2 years |
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