| 货号 | 18877-5mg |
| 描述 | Gardiquimod is an agonist of human toll-like receptor 7 (TLR7), but not human TLR8, although it activates both porcine TLR7 and TLR8.1 At 0.5 to 2 µg/ml, it enhances the immunosuppressive activity of T regulatory cells.2 Gardiquimod is effective as a mucosal adjuvant for Norwalk virus-like particles and inhibits infection of macrophages and T cells by HIV-1.3,4 It inhibits proliferation and migration while inducing apoptosis in pancreatic cancer cells in vitro.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Zhu, J.,Lai, K.,Bronile, R., et al. Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod. Molecular Immunology 45(11), 3238-3243 (2008). 2.Forward, N.A.,Furlong, S.J.,Yang, Y., et al. Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells. Journal of Leukocyte Biology 87(1), 117-125 (2010). 3.Velasquez, L.S.,Hjelm, B.E.,Arntzen, C.J., et al. An intranasally delivered Toll-like receptor 7 agonist elicits robust systemic and mucosal responses to Norwalk virus-like particles. Clinical and Vaccine Immunology 17(12), 1850-1858 (2010). 4.Buitendijk, M.,Eszterhas, S.K. and Howell, A.L. Gardiquimod: A toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells. AIDS Research and Human Retroviruses 29(6), 907-918 (2013). 5.Zou, B.B.,Wang, F.,Li, L., et al. Activation of Toll-like receptor 7 inhibits the proliferation and migration, and induces the apoptosis of pancreatic cancer cells. Mol.Med.Rep. 12(4), 6079-6085 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 313.4 |
| 分子式 | C17H23N5O |
| CAS号 | \ |
| 稳定性 | ≥ 2 years |
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