Azamulin
货号：
18748-500ug 基本售价：
546.0 元 规格：
500 ug
产品信息
概述| 货号 | 18748-500ug |
| 描述 | Azamulin is a selective, irreversible inhibitor of cytochrome P450 (CYP) 3A isoforms (IC50 values range from 26 to 240 nM for CYP3A4 and CYP3A4/5 from different sources).1 It is at least 50-fold less potent against CYP2J2 and 100-fold less effective against all other CYP isoforms.1 Azamulin potently blocks the hydroxylation of testosterone and midazolam by CYP3A4.1,2 |
| 别名 | Antibiotic TDM 85-530;SA 85530b; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Stresser, D.M.,Broudy, M.I.,Ho, T., et al. Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible. Drug Metabolism and Disposition 32(1), 105-112 (2004).
2.Lim, H.K.,Duczak, N., Jr.,Brougham, K., et al. Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes. Drug Metabolism and Disposition 33(8), 1211-1219 (2005).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 478.7 |
| 分子式 | C24H38N4O4S |
| CAS号 | 76530-44-4 |
| 稳定性 | ≥ 2 years |
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