Asoxime (chloride)
货号：
18607-5mg 基本售价：
546.0 元 规格：
5 mg
产品信息
概述| 货号 | 18607-5mg |
| 描述 | Organophosphates inactivate acetylcholinesterase (AChE) by reacting covalently with the active center serine, thus inhibiting its action of hydrolyzing acetylcholine at central and peripheral synapses. Acetylcholine accumulation results in an over-stimulation of cholinergic receptors, which can disrupt numerous biological functions. Asoxime is an asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates.1 It demonstrates therapeutic activity in experimental models of organophosphate poisoning, by reactivating phosphorylated AChE that was inhibited as a result of exposure to various cytotoxic nerve agents.2,3 |
| 别名 | HI-6; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wong, L.,Radic, Z.,Brüggermann, R.J.M., et al. Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis. Biochemistry 39(19), 5750-5757 (2000).
2.RamaRao, G.,Afley, P.,Acharya, J., et al. Efficacy of antidotes (midazolam, atropine and HI-6) on nerve agent induced molecular and neuropathological changes. BMC Neuroscience 15, (2014).
3.Cochran, R.,Kalisiak, J.,Küçükkilinç, T., et al. Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging. The Journal of Biological Chemisty 286(34), 29718-29724 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 359.2 |
| 分子式 | C14H16N4O3 • 2Cl |
| CAS号 | 34433-31-3 |
| 稳定性 | ≥ 2 years |
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