| 货号 | 18606-100mg |
| 描述 | Carbetapentane is an agonist of the sigma-1 receptor (Ki = 10.4 nM).1,2 It also binds the serotonin 5-HT3 and muscarinic acetylcholine receptors (Kis = 7.9 and 76 nM, respectively).3,4 Carbetapentane is a potent antitussive, anticonvulsant, and spasmolytic agent in clinical trials.2,4 |
| 别名 | Pentoxyverine citrate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ganapathy, M.E.,Prasad, P.D.,Huang, W., et al. Molecular and ligand-binding characterization of the σ-receptor in the Jurkat human T lymphocyte cell line. Journal of Pharmacology and Experimental Therapeutics 289(1), 251-260 (1999). 2.Brown, C.,Fezoui, M.,Selig, W.M., et al. Antitussive activity of sigma-1 receptor agonists in the guinea-pig. British Journal of Pharmacology 141(2), 233-240 (2004). 3.Bonhaus, D.W.,Loury, D.N.,Jakeman, L.B., et al. [3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus. Journal of Pharmacology and Experimental Therapeutics 267(2), 961-970 (1993). 4.Calderon, S.N.,Izenwasser, S.,Heller, B., et al. Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands. Journal of Medicinal Chemistry 37(15), 2285-2291 (1994). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 525.6 |
| 分子式 | C20H31NO3 • C6H8O7 |
| CAS号 | 23142-01-0 |
| 稳定性 | ≥ 2 years |
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