| 货号 | 18605-5mg |
| 描述 | N-acetyl Tryptamine is a structural analog of melatonin (5-methoxy-N-acetyltryptamine; Item No. 14427) that binds the melatonin MT2 receptor (Ki = 41 nM).1 It acts as a melatonin receptor antagonist in frog skin and chicken retina and as a partial agonist in rabbit retina.2,3,4 N-acetyl Tryptamine is also a reaction product of assays for serotonin N-acetyltransferase, the penultimate enzyme in the melatonin biosynthetic pathway.5 |
| 别名 | N-Acetyltryptamine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sugden, D.,Pickering, H.,Teh, M.T., et al. Melatonin receptor pharmacology: Toward subtype specificity. Biology of the Cell 89(8), 531-537 (1997). 2.Dubocovich, M.L. Characterization of a retinal melatonin receptor. Journal of Pharmacology and Experimental Therapeutics 234(2), 395-401 (1985). 3.Nonno, R.,Pannacci, M.,Lucini, V., et al. Ligand efficacy and potency at recombinant human MT2 melatonin receptors: Evidence for agonist activity of some mt1-antagonists. British Journal of Pharmacology 127(5), 1288-1294 (2016). 4.Dubocovich, M.L.,Masana, M.I.,Iacob, S., et al. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn-Schmiedebergs Archives of Pharmacology 355(3), 365-375 (1997). 5.DeAngelis, J.,Gastel, J.,Klein, D.C., et al. Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC 2.3.1.87). The Journal of Biological Chemisty 273(5), 3045-3050 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 202.3 |
| 分子式 | C12H14N2O |
| CAS号 | 1016-47-3 |
| 稳定性 | ≥ 2 years |
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