CH5424802
货号：
18516-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 18516-1mg |
| 描述 | Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. CH5424802 is an ATP-competitive inhibitor of ALK (IC50 = 1.9 nM) that also inhibits F1174L, R1275Q, and L1196M mutants of ALK (IC50s = 1.0, 3.5, and 1.6 nM, respectively).1,2 It shows more than 500-fold selectivity for ALK over a panel of 24 other kinases.1 CH5424802 is orally available and inhibits the growth of tumors in mouse xenograft models of nonsmall cell lung cancer and anaplastic large-cell lymphoma.1 |
| 别名 | Alectinib;RO5424802; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sakamoto, H.,Tskaguchi, T.,Hiroshima, S., et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell 19, 679-690 (2011).
2.Awad, M.M. and Shaw, A.T. ALK inhibitors in non-small cell lung cancer: Crizotinib and beyond. Clin. Adv. Hematol. Oncol. 12(7), 429-439 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 482.6 |
| 分子式 | C30H34N4O2 |
| CAS号 | 1256580-46-7 |
| 稳定性 | ≥ 2 years |
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