Quizartinib
货号：
17986-500ug 基本售价：
546.0 元 规格：
500 ug
产品信息
概述| 货号 | 17986-500ug |
| 描述 | Quizartinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3; Kd = 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.1,2 It inhibits the proliferation of the human leukemia cell line MV4-11, which harbors a homozygous FLT3-ITD mutation, with an IC50 value of 0.56 nM.1 At 1 mg/kg/day, quizartinib has been shown to extend survival in a mouse model of FLT3-ITD acute myeloid leukemia and to eradicate tumors in an FLT3-dependent mouse xenograft model at 10 mg/kg.2 |
| 别名 | AC220; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chao, Q.,Sprankle, K.G.,Grotzfeld, R.M., et al. Identification of N-(5-tert-butyl-isoxazol-3-yl)-N-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor. Journal of Medicinal Chemistry 52(23), 7808-7816 (2009).
2.Zarrinkar, P.P.,Gunawardane, R.N.,Cramer, M.D., et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 114(14), 2984-2992 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 560.7 |
| 分子式 | C29H32N6O4S |
| CAS号 | 950769-58-1 |
| 稳定性 | ≥ 2 years |
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