| 货号 | 17919-25mg |
| 描述 | N1-Acetylspermine is a monoacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.1 Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes.2,3N1-Acetylspermine has been used to study the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bolkenius, F.N. and Seiler, N. Acetylderivatives as intermediates in polyamine catabolism. International Journal of Biochemistry 13(3), 287-292 (1981). 2.Wallace, H.M.,Fraser, A.V. and Hughes, A. A perspective of polyamine metabolism. Biochemistry Journal 376(Pt 1), 1-14 (2003). 3.Igarashi, K. and Kashiwagi, K. Polyamines: Mysterious modulators of cellular functions. Biochemical and Biophysical Research Communications 271(3), 559-564 (2000). 4.Aouida, M.,Poulin, R. and Ramotar, D. The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. The Journal of Biological Chemisty 285(9), 6275-6284 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 353.8 |
| 分子式 | C12H28N4O • 3HCl |
| CAS号 | 77928-70-2 |
| 稳定性 | ≥ 2 years |
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