| 货号 | 17688-5mg |
| 描述 | Fenretinide is a synthetic retinoic acid (Item No. 11017) that induces ceramide in tumor cell lines, leading to caspase-dependent apoptosis (IC50 = 2.4 µM).1 It promotes the generation of reactive oxygen species, the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.2 At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ and is reported to inhibit the growth of Caov-3, OVCAR-3, and SK-OV-3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.3,4 |
| 别名 | 4-HPR;4-Hydroxy(phenyl)retinamide;MK-4016;Retinoic Acid p-hydroxyphenylamide;Ro 22-4667; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Erdreich-Epstein, A.,Tran, L.B.,Bowman, N.N., et al. Ceramide signaling in fenretinide-induced endothelial cell apoptosis. The Journal of Biological Chemisty 277(51), 49531-49537 (2002). 2.Ruvolo, V.R.,Karanjeet, K.B.,Schuster, T.F., et al. Role for PKCδ in fenretinide-mediated apoptosis in lymphoid leukemia cells. J.Signal Transduct. 2010, (2010). 3.Fontana, J.A. and Rishi, A.K. Classical and novel retinoids: Their targets in cancer therapy. Leukemia 16(4), 463-472 (2002). 4.Liu, S.,Brown, C.W.,Berlin, K.D., et al. Synthesis of flexible sulfur-containing heteroarotinoids that induce apoptosis and reactive oxygen species with discrimination between malignant and benign cells. Journal of Medicinal Chemistry 47, 999-1007 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 391.6 |
| 分子式 | C26H33NO2 |
| CAS号 | 65646-68-6 |
| 稳定性 | ≥ 2 years |
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