ZSTK474
货号：
17381-5mg 基本售价：
546.0 元 规格：
5 mg
产品信息
概述| 货号 | 17381-5mg |
| 描述 | ZSTK474 is a triazine derivative that acts as an inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms (IC50s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively).1 It is selective for PI3K, as it has negligible activity against 139 other kinases when tested at 30 µM.1 ZSTK474 is orally bioavailable and shows strong antitumor activity against human cancer xenografts in mice.1 The efficacy of ZSTK474 against certain cancer cells and tumors can be enhanced by combination therapy.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yaguchi, S.i.,Fukui, Y.,Koshimizu, I., et al. Antitumor activity of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor. Journal of the National Cancer Institute 98, 545-556 (2006).
2.Lin, L.,Gaut, D.,Hu, K., et al. Dual targeting of glioblastoma multiforme with a proteasome inhibitor (Velcade) and a phosphatidylinositol 3-kinase inhibitor (ZSTK474). International Journal of Oncology 44, 557-562 (2014).
3.Bertazza, L.,Barollo, S.,Radu, C.M., et al. Synergistic antitumour activity of RAF265 and ZSTK474 on human TT medullary thyroid cancer cells. Journal of Cellular and Molecular Medicine 19(9), 2244-2252 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 417.4 |
| 分子式 | C19H21F2N7O2 |
| CAS号 | 475110-96-4 |
| 稳定性 | ≥ 2 years |
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