| 货号 | 17292-10mg |
| 描述 | NPPB is a chloride channel blocker (IC50 = 80 nM) that has also been identified as a GPR35 agonist.1,2,3 It has been shown to activate the GPR35-Gαi/o and GPR35-Gα16 pathways in HEK293 cells, inducing intracellular calcium mobilization.3 NPPB has protonophoric activity and has been used to uncouple mitochondrial ATP synthesis in phagocytes.4 |
| 别名 | HOE 144;Hoechst 144; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Keeling, D.J.,Taylor, A.G. and Smith, P.L. Effects of NPPB (5-nitro-2-(3-phenylpropylamino)benzoic acid) on chloride transport in intestinal tissues and the T84 cell line. Biochimica et Biophysica Acta 1115(1), 42-48 (1991). 2.Bertollini, C.,Murana, E.,Mosca, L., et al. Transient increase in neuronal chloride concentration by neuroactive aminoacids released from glioma cells. Front.Mol.Neurosci. 5, 100 (2012). 3.Taniguchi, Y.,Tonai-Kachi, H. and Shinjo, K. 5-Nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist. Pharmacology 82(4), 245-259 (2008). 4.Lukacs, G.L.,Nanda, A.,Rotstein, O.D., et al. The chloride channel blocker 5-nitro-2-(3-phenylpropyl-amino) benzoic acid (NPPB) uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells. FEBS Letters 288(1-2), 17-20 (1991). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 300.3 |
| 分子式 | C16H16N2O4 |
| CAS号 | 107254-86-4 |
| 稳定性 | ≥ 2 years |
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