PK7242 (maleate)
货号：
17230-500ug 基本售价：
546.0 元 规格：
500 ug
产品信息
概述| 货号 | 17230-500ug |
| 描述 | The protein p53, often called the guardian of the genome, is a transcription factor that is activated in response to cellular stress (low oxygen levels, heat shock, DNA damage, etc.) and acts to prevent further proliferation of the stressed cell by promoting cell cycle arrest or apoptosis. Its role as a tumor suppressor is evident by the observation that approximately 50% of human tumors have mutated or non-functional p53. PK7242 is an inducer of reactivation of mutant p53 in cancer cells. In cancer cells carrying the Y220C mutant, PK7242 binds to the p53-Y220C core domain and induces growth inhibition, cell-cycle arrest, and apoptosis.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liu, X.,Wilcken, R.,Joerger, A.C., et al. Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Research 41(12), 6034-6044 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 414.4 |
| 分子式 | C17H19FN4 • C4H4O4 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
