| 货号 | 17154-25mg |
| 描述 | Galectins are a family of glycan-binding lectins with diverse regulatory roles in physiological processes.1,2 They have significant roles in inflammation and cancer.1,2 Thiodigalactoside is a diglycan that binds galectins-1, -3, -8, and -9 with Kd values between 24 and 78 µM.3,4 It is used to investigate the roles of these galectins in cell signaling and carcinogenesis.5,6,7 |
| 别名 | D-Galactopyranosyl-β-D-thiogalactopyranoside;TDG;Galactosyl 1-thiogalactoside; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ebrahim, A.H.,Alalawi, Z.,Mirandola, L., et al. Galectins in cancer: Carcinogenesis, diagnosis and therapy. Ann.Transl.Med. 2(9), 88-95 (2014). 2.Than, N.G.,Romero, R.,Balogh, A., et al. Galectins: Double-edged swords in the cross-roads of pregnancy complications and female reproductive tract inflammation and neoplasia. J.Path.Trans.Med. 49, 181-208 (2015). 3.Salameh, B.A.,Cumpstey, I.,Sundin, A., et al. 1H-1,2,3-triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors. Bioorg.Med.Chem 18(14), 5367-5378 (2010). 4.van Hattum, H.,Branderhorst, H.M.,Moret, E.E., et al. Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1. Journal of Medicinal Chemistry 56(3), 1350-1354 (2013). 5.Ito, K.,Scott, S.A.,Cutler, S., et al. Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress. Angiogenesis 14, 293-307 (2011). 6.Kuo, P.,Bratman, S.V.,Shultz, D.B., et al. Galectin-1 mediated radiation-related lymphopenia and attenuates NSCLC radiation response. Clinical Cancer Research 20(21), 5558-5569 (2014). 7.Mukherjee, R.,Kim, S.W.,Park, T., et al. Targeted inhibition of galectin 1 by thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats. Int.J.Obes.(Lond). (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 358.4 |
| 分子式 | C12H22O10S |
| CAS号 | 51555-87-4 |
| 稳定性 | ≥ 2 years |
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