SB-224289 (hydrochloride)
货号：
17036-5mg 基本售价：
546.0 元 规格：
5 mg
产品信息
概述| 货号 | 17036-5mg |
| 描述 | The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-224289 is a potent 5-HT1B inverse agonist (pKi = 8.16) that displays >75-fold selectivity for human 5-HT1B over all other 5-HT receptors.1 It has been used to study the role of 5-HT1B receptors in cocaine self-administration and cocaine-seeking behavior.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Selkirk, J.V.,Scott, C.,Ho, M., et al. SB-224289 -- A novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity. British Journal of Pharmacology 125(1), 202-208 (1998).
2.Pentkowski, N.S.,Harder, B.G.,Brunwasser, S.J., et al. Pharmacological evidence for an abstinence-induced switch in 5-HT1B receptor modulation of cocaine self-administration and cocaine-seeking behavior. ACS Chem.Neurosci. 5(3), 168-176 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 557.1 |
| 分子式 | C32H32N4O3 • HCl |
| CAS号 | 180084-26-8 |
| 稳定性 | ≥ 2 years |
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